He wrote, in part, that he and his wife, Morgan, lost their baby on Sunday morning, around 4 a.m. due to complications; he had to be delivered prematurely.
Goodwin not only played, but he caught an 83-yard touchdown pass helping to bring the 49ers to victory against the Giants.
Goodwin had Giants' corner Janoris Jenkins beat, and ran the last 20 or so yards to the end zone alone.
According to NBC Sports, Goodwin left the locker room quickly after the game to be with his family.
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Just months earlier, Goodwin and his wife, Morgan, revealed they were expecting a child.
And when Goodwin scored the TD, he gripped the football tight, looked up to the sky and emotionally broke down in the end zone in this heartbreaking moment.
"Although we are hurt, I am grateful for the experience and grateful that God blessed me with a wife as courageous and resilient as Morgan", he wrote.
After the game, Goodwin shared a photo to his Instagram account, including a message that explained what had happened. Former wide receiver Stevie Johnson, a former teammate of Goodwin's with the Bills, said on Twitter he was "praying for you and your fam", adding "We send you all our love and support". The baby was born premature and died early Sunday morning after complications, KTVU reported.
Goodwin asked his fans to pray for his family.