The New York Fire Department said almost two dozen people were injured, including a firefighter.
The fire started around 5:30 a.m.
A fire destroyed a building and injured 16 people in the Bronx on Tuesday, just days after the worst fire in New York City in 25 years killed 12 people.
As flames worked their way upward from a furniture store to the flats above, families, including children, were forced out into historically low winter temperatures.
Flames and smoke could be seen pouring from the building.
A huge fire engulfed a Bronx apartment building overnight. But fire officials say almost two dozen people, including that man and his family, have been displaced by the blaze.
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The displaced residents were placed on an nearby bus so they could keep warm while firefighters continued battling the inferno.
"Our units arrived and were immediately faced with heavy fire".
Five hours later, the fire crews were still fighting to control the blaze on the Bronx's Commonwealth Avenue.
"Praying for a swift recovery for all those injured", Mayor Bill de Blasio tweeted.
On Thursday, 12 people, including children, died in a fast-moving fire in the Bronx, also near the zoo.
All of the residents of the building were believed to have been evacuated as well.