With Messi likely to be named in the Argentina line-up against Spain for their friendly clash on Tuesday at the Wanda Metropolitano in Madrid, the Red Devils goalkeeper will be more than happy if he gets a busy night on goal.
"It's the official ball of the World Cup, and everyone is kicking and screaming about it, but it is what it is", Lopetegui said.
"Leo, you have to listen to him, create situations that will be optimal for him and from there build a team in relation to that". "We never, at any point, think about risking him".
Nevertheless, the occasionally feisty nature of their Clasico showdowns does not give Sampaoli any cause for concern over Messi's fitness.
However, the two-time World Cup winners will be without Angel di Maria, who hurt his thigh against Italy, and Sergio Aguero, with the Manchester City striker recovering from a knee injury.
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La Joya was left out of the squad for the games with Italy and Spain, as was Inter captain Mauro Icardi.
Spain drew 1-1 with Germany in Dusseldorf on Friday, extending their unbeaten record under Julen Lopetegui to 17 matches.
'Right now we're not among the contenders to win the World Cup, ' argued the Barcelona star.
'Alongside me in the national team he had to play more on the left, maybe he's not so used to that.
"To see what will make us work like a team", admitting that while Argentina still had work to do to decide their strongest side, "Spain have their side already consolidated. if they are not the best side in the world, they are among the best".
"We've just played the world champions (Germany) and now face the runners-up who have an incredible player, who collectively have improved with the arrival of Sampaoli".